Modeling helps in understanding antidepressants

N Holford - Clinical Pharmacology & Therapeutics, 2012 - Wiley Online Library
Clinical Pharmacology & Therapeutics, 2012Wiley Online Library
The clinical pharmacology of antidepressant drugs is challenging to describe because of
difficulties in describing the depressed state, the time course of response to a treatment
intervention, and the frequent withdrawal of patients from clinical trials. Many of these
challenges were addressed in a recent article by Russu et al. in this journal. Clinical
Pharmacology & Therapeutics (2012); 92 2, 155–156. doi: 10.1038/clpt. 2012.88
The clinical pharmacology of antidepressant drugs is challenging to describe because of difficulties in describing the depressed state, the time course of response to a treatment intervention, and the frequent withdrawal of patients from clinical trials. Many of these challenges were addressed in a recent article by Russu et al. in this journal.
Clinical Pharmacology & Therapeutics (2012); 92 2, 155–156. doi:10.1038/clpt.2012.88
Wiley Online Library
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